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Computational & Functional Genomics » Research |
| Computational & Functional Genomics |
"We harness the synergy of computing and experiments to address challenges in biology"
- Akash Ranjan |
We study genomic encoding of molecular mechanisms and circuits that control cellular functions in physiology and pathology. We have developed many computational and experimental approaches to unravel genomic encoding of physiological function. We are currently applying these approaches to study the physiology and pathology associated with bacterial pathogens (such as pathogenic E.coli and M. tuberculosis), apicomplexan parasites (such as Plasmodia etc.) and humans. Under this theme, we are working on:
- Study of amino acid substitution pattern in apicomplexan parasites and its impact on improving genome annotations and functional characterization.
- Structural and functional studies of P. falciparum proteins associated with parasite physiology and human pathology.
- Structural and functional characterization of transcription initiation regulators and their regulons in physiology and pathology.
- Physiological machinery for sensing and modulation of proteins aggregation in human cells. Role of HYPK, VCP and Nedd proteins in human neurodegereative diseases.
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| Last updated on: Tuesday,5th June, 2018 |
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