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Dr.Rashna Bhandari
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Home » Cell Signalling » Publications
Publications
  1. Aggarwal S.,† Vineeth V.S.*, Padwal S.S.*, Bhat S.A., Singh A., Kulkarni A., Patil M., Tallapaka K., Pasumarthi D., Venkatapuram V., Thotakura P.L., Dalal A.B., and Bhandari R.† SERPINA11 related novel serpinopathy - a perinatal lethal disorder. Clinical Genetics (2024) (in press)

  2. Morgan J.A.M.*, Singh A.*, Kurz L., Nadler-Holly M., Penkert M., Krause E., Liu F., Bhandari R.†, and Fiedler D.† Extensive protein pyrophosphorylation revealed in human cell lines. Nature Chemical Biology (2024) DOI: 10.1038/s41589-024-01613-5 (Online ahead of print)

  3. Khan A., Mallick M., Ladke J.S. and Bhandari R.† The ring rules the chain—inositol pyrophosphates and the regulation of inorganic polyphosphate. Biochemical Society Transactions, (2024) 52, 567–580.

  4. Bhat S.A., Malla A.B., Oddi V. Sen J., Bhandari R.† Inositol hexakisphosphate kinase 1 is essential for cell junction integrity in the mouse seminiferous epithelium Biochemica et Biophysica Acta – Molecular Cell Research (2024) 1871, 119596.

  5. Shah A. and Bhandari R.✝ IP6K1 upregulates the formation of processing bodies by influencing protein-protein interactions on the mRNA cap Journal of Cell Science (2021) 134(24):jcs259117

  6. Shukla A., Kaur M., Kanwar S., Kaur G., Sharma S., Ganguli S., Kumari V., Mazumder K., Pandey P., Rouached H., Rishi V., Bhandari R., and Pandey A.K.✝ Wheat inositol pyrophosphate kinase TaVIH2-3B modulates cell-wall composition and drought tolerance in Arabidopsis. BMC Biology (2021) 19, 1-23

  7. Mohanrao R., Manorama R., Ganguli S., Madhusudhanan M.C., Bhandari R.✝ and Sureshan K.M.✝ Novel substrates for kinases involved in the biosynthesis of inositol pyrophosphates and their enhancement of ATPase activity of a kinase Molecules (2021) 26, 3601

  8. Lolla P.*, Shah A.*, Unnikannan C.P., Oddi V. and Bhandari R✝. Inositol pyrophosphates promote MYC polyubiquitination by FBW7 to regulate cell survival Biochemical Journal (2021) 478, 1647-1661. (Cover image).

  9. Chanduri M and Bhandari R. Back-pyrophosphorylation assay to detect in vivo InsP7-dependent protein pyrophosphorylation in mammalian cells. Methods in Molecular Biology (2020) 2091, 93-105.

  10. Ganguli S, Shah S, Hamid A, Singh A, Palakurti R and Bhandari R. A high energy phosphate jump - from pyrophospho-inositol to pyrophospho-serine. Advances in Biological Regulation (2019) 75, 100662

  11. Shaunak Deota, Sivasudhan Rathnachalam, Kanojia Namrata, Mayank Boob, Amit Fulzele, S Radhika, Shubhra Ganguli, Chinthapalli Balaji, Stephanie Kaypee, Krishna Kant Vishwakarma, Tapas Kumar Kundu, Rashna Bhandari, Anne Gonzalez de Peredo, Mithilesh Mishra, Ravindra Venkatramani, Ullas Kolthur-Seetharam. Allosteric regulation of cyclin-B binding by the charge state of catalytic lysine in CDK1 is essential for cell-cycle progression. Journal of Molecular Biology (2019) 431, 2127-2142

  12. Singh J., Steck N., De D., Hofer A., Ripp A., Captain I., Keller M., Wender P.A., Bhandari R., and Jessen H.J.✝ A phosphoramidite analogue of cyclotriphosphate enables iterative polyphosphorylations. Angewandte Chemie (2019) 58, 3928-3933.

  13. Ansari M.Z., Kumar A., Ahari D., Priyadarshi A., Padmavathi L., Bhandari R. and Swaminathan R. Protein charge transfer absorption spectra: an intrinsic probe to monitor structural and oligomeric transitions in proteins. Faraday Discussions (2018) 207, 91-113

  14. Malla A.B. and Bhandari R. IP6K1 is essential for chromatoid body formation and temporal regulation of TNP2 and PRM2 expression in mouse spermatids. Journal of Cell Science (2017) 130, 2854-2866. (Cover image)

  15. Shah A., Ganguli S., Sen J. and Bhandari R. Inositol pyrophosphates: energetic, omnipresent and versatile signalling molecules. Journal of the Indian Institute of Science (2017), 97, 23–40.

  16. Chanduri M., Rai A., Malla A.B., Wu M., Fiedler D., Mallik R. and Bhandari R. Inositol hexakisphosphate kinase 1 (IP6K1) activity is required for cytoplasmic dynein-driven transport. Biochemical Journal (2016) 473, 3031-3047.

  17. Jadav R.S., Kumar D., Buwa N., Ganguli S., Thampatty S.R., Balasubramanian N. and Bhandari R. Deletion of inositol hexakisphosphate kinase 1 (IP6K1) reduces cell migration and invasion, conferring protection from aerodigestive tract carcinoma in mice. Cellular Signalling (2016) 28, 1124-1136.

  18. Thota S.G. and Bhandari R. The emerging roles of inositol pyrophosphates in eukaryotic cell physiology. J. Biosci. (2015) 40, 593-605.

  19. Thota S.G., Unnikannan C.P., Thampatty S.R., Manorama R. and Bhandari R. Inositol pyrophosphates regulate RNA polymerase I-mediated rRNA transcription in Saccharomyces cerevisiae. Biochemical Journal (2015) 466, 105-114.

  20. Ghosh S., Shukla D., Suman K., Lakshmi B.J., Manorama R., Kumar S. and Bhandari R. Inositol hexakisphosphate kinase 1 maintains hemostasis in mice by regulating platelet polyphosphate levels. Blood (2013) 122, 1478-1486.

  21. Jadav R.S., Chanduri M.V.L., Sengupta S. and Bhandari R . Inositol Pyrophosphate Synthesis by Inositol Hexakisphosphate Kinase 1 is Required for Homologous Recombination Repair. J. Biol. Chem. (2013) 288, 3312-3321.

  22. Werner J.K. Jr., Speed T. and Bhandari R. Protein pyrophosphorylation by diphosphoinositol pentakisphosphate (InsP7). Methods Mol Biol. (2010) 645, 87-102.

  23. Basu N., Bhandari R., Natarajan V.T. and Visweswariah S.S. Cross talk between receptor guanylyl cyclase C and c-src tyrosine kinase regulates colon cancer cell cytostasis. Mol. Cell. Biol. (2009) 29, 5277-5289.

  24. Ponnusamy S., Alderson N.L., Hama H., Bielawski J., Jiang J.C., Bhandari R., Snyder S.H., Jazwinski S.M. and Ogretmen B. Regulation of telomere length by fatty acid elongase 3 in yeast: Involvement of inositol phosphate metabolism and ku70/80 function. Journal of Biological Chemistry (2008) 283, 27514-27524.

  25. Draskovic P., Saiardi A., Bhandari R., Burton A., Ilc G., Kovacevic M., Snyder S.H. and Podobnik M. Inositol hexakisphosphate kinase products contain diphosphate and triphosphate groups. Chemistry & Biology (2008)15, 274-286.

  26. Bhandari R.*, Juluri K.R.*, Resnick A.C. and Snyder S.H. Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesis. Proc. Natl. Acad. Sci. USA (2008) 105, 2349-2353.


  27. Bhandari R., Saiardi A., Ahmadibeni Y., Snowman A.M., Resnick A.C., Kristiansen T.Z., Molina H., Pandey A., Werner J.K., Juluri K.R., Xu Y., Prestwich G. D., Parang K. and Snyder S.H. Protein pyrophosphorylation by inositol pyrophosphates is a posttranslational event. Proc. Natl. Acad. Sci. USA (2007) 104, 1530 5-15310.


  28. Bhandari R., Chakraborty A. and Snyder S.H. Inositol pyrophosphate pyrotechnics. Cell Metabolism (2007) 5, 321-323.


  29. Kim Y., Bhandari R., Cochran J.R., Kuriyan J. and Wittrup K.D. Directed evolution of the epidermal growth factor receptor extracellular domain for expresionin yeast. Proteins: Structure, Function, and Bioinformatics (2006) 62, 1026-1035.


  30. Saiardi A.*, Bhandari R.*, Resnick A.C., Snowman A.M. and Snyder S.H.Phosphorylation of proteins by inositol pyrophosphates. Science (2004) 306, 2101-2105.


  31. Cochran J.R., Kim Y.S., Olsen M.J., Bhandari R. and Wittrup K.D. Domain-level antibody epitope mapping through yeast surface display of epidermal growth factor receptor fragments. J. Immunol. Methods (2004) 287, 147-158.

  32. Chen X.*, Bhandari R.*, Vinkemeier U., van den Akker F, Darnell J.E. Jr. and Kuriyan J. A re-interpretation of the dimerization domain interface of the N-terminal domains of STATs. Protein Sci. (2003) 12, 361-365.

  33. Bhandari R. and Kuriyan J. JAK-STAT Signaling. (2003) in Handbook of Cell Signaling, Membrane Proximal Events (Alber T., Ed.), Volume 1, Chapter 62; Academic Press/Elsevier Science.

  34. Bhandari R., Srinivasan N., Mahaboobi M., Ghanekar Y., Suguna K. and Visweswariah S.S. Functional inactivation of the human guanylyl cyclase C receptor: modeling and mutation of the protein kinase-like domain. Biochemistry (2001) 40, 9196-9206.

  35. Bhandari R., Mathew R., Vijayachandra K. and Visweswariah S.S. Tyrosine phosphorylation of the human guanylyl cyclase C receptor. J. Biosciences (2000) 25, 339-346.

  36. Vijayachandra K., Guruprasad M.R., Bhandari R., Manjunath U.H., Somesh B.P., Srinivasan N., Suguna K. and Visweswariah S.S. Biochemical characterisation of the intracellular domain of the human guanylyl cyclase C receptor provides evidence for a catalytically active homotrimer. Biochemistry (2000) 39, 16075-16083.

  37. Bhandari R., Suguna K. and Visweswariah S.S. Guanylyl cyclase C receptor: regulation of catalytic activity by ATP. Biosci. Rep. (1999) 19, 179-188.

  38. Nandi A., Bhandari R. and Visweswariah S.S. Epitope conservation and immunohistochemical localization of the guanylin/stable toxin peptide receptor, guanylyl cyclase C. J. Cell. Biochem. (1997) 66, 500-511.

  39. Bhandari R. and Brahmachari S.K. Analysis of CAG/CTG triplet repeats in the human genome: Implication in transcription factor gene regulation. J. Biosciences (1995) 20, 613-627.

    *Both authors contributed equally to this work
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Email: rashna<at>cdfd.org.in
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Last updated on: Monday, 10th June, 2024

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